卵巢癌
生物
小RNA
顺铂
癌变
基因敲除
癌症研究
异位表达
蛋白激酶B
癌症
信号转导
生物信息学
化疗
细胞培养
细胞生物学
基因
遗传学
作者
Xuan Meng,Xiaoqing Liang,Shengjie Yang,Dongsheng Wu,Xinghe Wang
标识
DOI:10.1016/j.yexcr.2024.114012
摘要
Ovarian cancer is one of the most common gynecological tumors worldwide. Despite the availability of multiple treatments for ovarian cancer, its resistance to chemotherapy remains a significant challenge. miRNAs play crucial roles in the initiation and progression of cancer by affecting processes such as differentiation, proliferation, and chemoresistance. According to microarray and qPCR analyses, miR-7704 is significantly downregulated in cisplatin-resistant cells compared to parental cells. In this study, we found that miR-7704 inhibited the proliferation and promoted cisplatin sensitivity of ovarian cancer cells in vitro and in vivo. Moreover, ectopic expression of miR-7704 had the same effect as IL2RB knockdown. Further mechanistic studies revealed that miR-7704 played an inhibitory role by regulating IL2RB expression to inactivate the AKT signaling pathway. Furthermore, IL2RB reversed the miR-7704 mediated resistance to cisplatin in ovarian cancer. Based on these findings, miR-7704 and IL2RB show the potential as novel therapeutic targets for ovarian cancer.
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