涂层
药品
微观结构
气球
材料科学
医学
纳米技术
药理学
内科学
冶金
作者
Tarek Shazly,Tarek Shazly,Tarek Shazly,John F. Eberth,Colton J. Kostelnik,Colton J. Kostelnik,Mark J. Uline,Mark J. Uline,Mark J. Uline,Vipul C. Chitalia,Vipul C. Chitalia,Francis G. Spinale,Francis G. Spinale,Francis G. Spinale,Ahmed Alshareef,Ahmed Alshareef,Ahmed Alshareef,Vijaya B. Kolachalama,Vijaya B. Kolachalama
出处
期刊:ACS applied bio materials
[American Chemical Society]
日期:2024-04-25
标识
DOI:10.1021/acsabm.4c00080
摘要
Drug-coated balloon (DCB) therapy is a promising endovascular treatment for obstructive arterial disease. The goal of DCB therapy is restoration of lumen patency in a stenotic vessel, whereby balloon deployment both mechanically compresses the offending lesion and locally delivers an antiproliferative drug, most commonly paclitaxel (PTX) or derivative compounds, to the arterial wall. Favorable long-term outcomes of DCB therapy thus require predictable and adequate PTX delivery, a process facilitated by coating excipients that promotes rapid drug transfer during the inflation period. While a variety of excipients have been considered in DCB design, there is a lack of understanding about the coating-specific biophysical determinants of essential device function, namely, acute drug transfer. We consider two hydrophilic excipients for PTX delivery, urea (UR) and poly(ethylene glycol) (PEG), and examine how compositional and preparational variables in the balloon surface spray-coating process impact resultant coating microstructure and in turn acute PTX transfer to the arterial wall. Specifically, we use scanning electron image analyses to quantify how coating microstructure is altered by excipient solid content and balloon-to-nozzle spray distance during the coating procedure and correlate obtained microstructural descriptors of coating aggregation to the efficiency of acute PTX transfer in a one-dimensional ex vivo model of DCB deployment. Experimental results suggest that despite the qualitatively different coating surface microstructures and apparent PTX transfer mechanisms exhibited with these excipients, the drug delivery efficiency is generally enhanced by coating aggregation on the balloon surface. We illustrate this microstructure–function relation with a finite element-based computational model of DCB deployment, which along with our experimental findings suggests a general design principle to increase drug delivery efficiency across a broad range of DCB designs.
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