主要组织相容性复合体
生物
T细胞
计算生物学
免疫系统
四聚体
免疫学
生物化学
酶
作者
Rahul Tiwari,Vishal Kumar Singh,Rajneesh,Awnish Kumar,Vibhav Gautam,Rajiv Kumar
出处
期刊:Advances in protein chemistry and structural biology
日期:2024-01-01
卷期号:: 327-345
标识
DOI:10.1016/bs.apcsb.2024.02.002
摘要
Major histocompatibility complex (MHC) tetramers stand as formidable tools within T cell biology, facilitating the exploration and comprehension of immune responses. These artificial molecules, comprising four bound MHC molecules, typically with a specified peptide and a fluorescent label, play a pivotal role in characterizing T cell subsets, monitoring clonal expansion, and unraveling T cell dynamics during responses to infections or immunotherapies. Beyond their applications in T cell biology, MHC tetramers prove valuable in investigating a spectrum of diseases such as infectious diseases, autoimmune disorders, and cancers. Their instrumental role extends to vaccine research and development. Notably, when appropriately configured, tetramers transcend T cell biology research and find utility in exploring natural killer T cells and contributing to specific T cell clonal deletions.
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