平滑肌肿瘤
病理
免疫组织化学
间质细胞
异型性
医学
间充质干细胞
平滑肌
有丝分裂指数
核异型性
有丝分裂
生物
内科学
细胞生物学
出处
期刊:Advances in Anatomic Pathology
[Ovid Technologies (Wolters Kluwer)]
日期:2024-04-19
标识
DOI:10.1097/pap.0000000000000446
摘要
Uterine smooth muscle tumors are a heterogeneous group of mesenchymal neoplasms with multiple histologic variants and distinct biological behaviors. Pathologic classification (benign, uncertain malignant potential, malignant) relies on the evaluation of mitotic index, necrosis, and degree of cytologic atypia, with different thresholds based on each subtype. Immunohistochemistry and other ancillary studies may be necessary to establish the diagnosis in a subset of cases, given the morphologic overlap with other mesenchymal neoplasms, including low-grade and high-grade endometrial stromal tumors, inflammatory myofibroblastic tumors, and PEComa. Recent advances in molecular diagnostics have refined the classification of smooth muscle tumors, but most cases are diagnosed purely on histologic grounds.
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