Two new lignans from the fresh roots of Zhongsheng No.1 Rehmannia glutinosa

Two new undescribed compounds, jiofuran acid A (1) and 8′-hydroxyl episesaminone (2), together with seven known compounds (3–9) were isolated from the fresh roots of Zhongsheng No.1 Rehmannia glutinosa. Their structures were established by spectroscopic techniques (HR-ESI-MS, 1D NMR, 2D NMR), and absolute configurations were resolved by comparing their experimental and calculated ECD spectra. Bioassay results demonstrated compounds 1–3 exhibited the obvious anti-pulmonary fibrosis activity.