Synergistic Chemoimmunotherapy Augmentation via Sequential Nanocomposite Hydrogel‐Mediated Reprogramming of Cancer‐Associated Fibroblasts in Osteosarcoma (Adv. Mater. 15/2024)

Sequential Nanocomposite Hydrogel In article number 2309591, Ran Wei, Yujing Li, Huan Meng, and co-workers report a new sequential nanocomposite hydrogel that is capable of reshaping cancer-associated fibroblast behavior, therefore enhancing tumor-infiltrating T-cells in osteosarcoma. The capability for sequential drug release underscores the competitive advantage of a smart nano-enabled machinery design to address the complex tumor immunological environment for effective management of osteosarcoma.