Efficacy of acupuncture for depression: a systematic review and meta-analysis

针灸科 哈姆德 医学 随机对照试验 荟萃分析 梅德林 萧条(经济学) 心理干预 不利影响 数据提取 临床试验 物理疗法 替代医学 内科学 精神科 焦虑 病理 经济 宏观经济学 政治学 法学
作者
Yawen Tan,Runping Duan,Chuanbiao Wen
出处
期刊:Frontiers in Neuroscience [Frontiers Media]
卷期号:18
标识
DOI:10.3389/fnins.2024.1347651
摘要

Introduction Depression is a pervasive mental health challenge with substantial global ramifications. Contemporary therapeutic strategies predominantly consist of psychological interventions and pharmacological treatments. Acupuncture, deeply rooted in ancient traditions and bolstered by a plethora of clinical trials, demonstrates considerable efficacy in depression. This study aims to elucidate the efficacy and safety of acupuncture as a standalone therapy for depression patients by reviewing randomized controlled trials that compare acupuncture treatment with conventional drug therapy. Methods Comprehensive searches were conducted across six databases in both Chinese and English: CNKI, Wanfang, VIP, Embase, Medline, and CENTRAL. The literature search spanned from 1 July 2013, to 1 July 2023. Two researchers independently carried out literature screening and data extraction. Review Manager 5.4 was utilized for data analysis and bias risk assessment. A total of 20 randomized controlled trials were included in the qualitative synthesis, involving 1,376 participants and 43 relevant acupoints. Results The Meta-analysis results, based on the HAMD scale scores, revealed that acupuncture regimens (RR: −1.63; 95% CI: −2.49 to −0.76; P = 0.0002; I 2 = 86%; n = 1,668) were significantly more effective compared to standalone medication. Moreover, efficacy metrics from the HAMD highlighted a substantial advantage of acupuncture (RR: 2.6; 95% CI: 1.6 to 4.23; P = 0.0001; I 2 = 0; n = 614). Further assessments utilizing SERS and TESS demonstrated a lower incidence of side effects and adverse outcomes in the acupuncture group. Conclusions Acupuncture, when compared to conventional pharmacotherapy, exhibits significant efficacy as a standalone treatment after four weeks of intervention, with fewer side effects and adverse reactions. However, further investigation is needed to determine the most effective acupoints and appropriate types of acupuncture techniques for treating depression. Systematic review registration https://www.crd.york.ac.uk/prospero/ , identifier CRD42023443711.
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