免疫疗法
肿瘤微环境
肺癌
巨噬细胞
癌症研究
免疫系统
肿瘤相关巨噬细胞
肺
癌变
转移
癌症
先天免疫系统
免疫学
生物
医学
病理
内科学
体外
生物化学
作者
Sheng Wang,Qing Gao,Jinghong Wu,Mingjun Lu,Jinghui Wang,Teng Ma
标识
DOI:10.1002/adbi.202400119
摘要
The lungs are the largest surface of the body and the most important organ in the respiratory system, which are constantly exposed to the external environment. Tissue Resident Macrophages in lung constitutes the important defense against external pathogens. Macrophages connects the innate and adaptive immune system, and also plays important roles in carcinogenesis and cancer immunotherapy. Lung cancer is the leading cause of cancer-related death worldwide, with an overall five-year survival rate of only 21%. Macrophages that infiltrate or aggregate in lung tumor microenvironment are defined as tumor-associated macrophages (TAMs). TAMs are the main components of immune cells in the lung tumor microenvironment. The differentiation and maturation process of TAMs can be roughly divided into two different types: classical activation pathway produces M1 tumor-associated macrophages, and bypass activation pathway produces M2 tumor-associated macrophages. Studies have found that TAMs are related to tumor invasion, metastasis, and treatment resistance, and show potential as a new target for tumor immunotherapy. Therefore, the biological function of macrophages in lung and the role of TAMs in the occurrence, development, and treatment of lung cancer are discussed in this paper.
科研通智能强力驱动
Strongly Powered by AbleSci AI