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Determinants of clinical outcomes of gastric cancer patients treated with neoadjuvant chemotherapy: a sub-analysis of the PRODIGY study

医学 内科学 化疗 肿瘤科 外科肿瘤学 阶段(地层学) 围手术期 癌症 疾病 人口 胃肠病学 外科 生物 环境卫生 古生物学
作者
Hyung‐Don Kim,Jong Seok Lee,Young Soo Park,Jeong Hwan Yook,Sung Hoon Noh,Youngkyu Park,Young‐Woo Kim,Sang Cheul Oh,Jong Gwang Kim,Min‐Hee Ryu,Jae‐Ho Cheong,Hyunki Kim,Joon Seok Lim,Jae-Hyuk Lee,Suk Hee Heo,Jin Young Kim,Mi Hwa Heo,Young Iee Park,Inho Kim,Yoon‐Koo Kang
出处
期刊:Gastric Cancer [Springer Science+Business Media]
卷期号:25 (6): 1039-1049 被引量:4
标识
DOI:10.1007/s10120-022-01325-6
摘要

In this post hoc analysis of the PRODIGY study, we aimed to investigate factors associated with survival outcomes and provide evidence for designing optimal perioperative treatment strategies for gastric cancer patients receiving neoadjuvant chemotherapy.A total of 212 patients in the neoadjuvant chemotherapy group of the PRODIGY study were included as the study population. The prognostic impact of clinicopathologic factors, including the initial radiological clinical stage (cStage) and post-neoadjuvant chemotherapy pathological stage (ypStage), was analyzed.The median age was 58 years. The majority of patients (77.4%) had cStage III disease, and about 10% and 25% had ypStage 0 and I disease, respectively. According to the initial cStage, progression-free survival (PFS) and overall survival (OS) were significantly different (P < 0.01). PFS and OS were also different according to the ypStage (P < 0.01). In multivariate analyses, cStage IIIC disease (vs. cStage II) and ypStage II and III disease (vs. ypStage 0/I) were independent factors for poor survival outcomes. Based on the patterns of PFS and OS according to both cStage and ypStage, three patient groups were defined. These groups showed distinct PFS and OS (P < 0.01) with 5-year PFS rates of 95.7%, 77.9%, and 31.3% and 5-year OS rates of 95.7%, 82.4%, and 42.5%, respectively.Both initial cStage and ypStage were independent factors for survival outcomes of gastric cancer patients treated with neoadjuvant chemotherapy. Efforts should be made to develop optimal peri-operative treatment strategies for patients at different risks according to cStage and ypStage.
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