Determinants of clinical outcomes of gastric cancer patients treated with neoadjuvant chemotherapy: a sub-analysis of the PRODIGY study

医学 内科学 化疗 肿瘤科 外科肿瘤学 阶段(地层学) 围手术期 癌症 疾病 人口 胃肠病学 外科 生物 环境卫生 古生物学
作者
Hyung‐Don Kim,Jong Seok Lee,Young Soo Park,Jeong Hwan Yook,Sung Hoon Noh,Youngkyu Park,Young‐Woo Kim,Sang Cheul Oh,Jong Gwang Kim,Min‐Hee Ryu,Jae‐Ho Cheong,Hyunki Kim,Joon Seok Lim,Jae-Hyuk Lee,Suk Hee Heo,Jin Young Kim,Mi Hwa Heo,Young Iee Park,Inho Kim,Yoon‐Koo Kang
出处
期刊:Gastric Cancer [Springer Science+Business Media]
卷期号:25 (6): 1039-1049 被引量:4
标识
DOI:10.1007/s10120-022-01325-6
摘要

In this post hoc analysis of the PRODIGY study, we aimed to investigate factors associated with survival outcomes and provide evidence for designing optimal perioperative treatment strategies for gastric cancer patients receiving neoadjuvant chemotherapy.A total of 212 patients in the neoadjuvant chemotherapy group of the PRODIGY study were included as the study population. The prognostic impact of clinicopathologic factors, including the initial radiological clinical stage (cStage) and post-neoadjuvant chemotherapy pathological stage (ypStage), was analyzed.The median age was 58 years. The majority of patients (77.4%) had cStage III disease, and about 10% and 25% had ypStage 0 and I disease, respectively. According to the initial cStage, progression-free survival (PFS) and overall survival (OS) were significantly different (P < 0.01). PFS and OS were also different according to the ypStage (P < 0.01). In multivariate analyses, cStage IIIC disease (vs. cStage II) and ypStage II and III disease (vs. ypStage 0/I) were independent factors for poor survival outcomes. Based on the patterns of PFS and OS according to both cStage and ypStage, three patient groups were defined. These groups showed distinct PFS and OS (P < 0.01) with 5-year PFS rates of 95.7%, 77.9%, and 31.3% and 5-year OS rates of 95.7%, 82.4%, and 42.5%, respectively.Both initial cStage and ypStage were independent factors for survival outcomes of gastric cancer patients treated with neoadjuvant chemotherapy. Efforts should be made to develop optimal peri-operative treatment strategies for patients at different risks according to cStage and ypStage.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
唯美发布了新的文献求助10
2秒前
hnlgdx发布了新的文献求助10
6秒前
一根完成签到,获得积分20
6秒前
七月完成签到 ,获得积分10
8秒前
xiaojiahuo完成签到,获得积分10
9秒前
10秒前
猪猪hero发布了新的文献求助10
10秒前
自信不愁完成签到,获得积分10
11秒前
潇湘雪月发布了新的文献求助10
12秒前
Arthur完成签到,获得积分10
13秒前
13秒前
量子星尘发布了新的文献求助10
14秒前
芋孟齐完成签到,获得积分20
14秒前
猪猪hero发布了新的文献求助10
16秒前
17秒前
高手发布了新的文献求助10
17秒前
17秒前
WN发布了新的文献求助10
17秒前
超级的鹅发布了新的文献求助10
20秒前
FashionBoy应助axin采纳,获得10
21秒前
胡霖完成签到,获得积分10
22秒前
流飒完成签到,获得积分10
22秒前
香蕉觅云应助牛马码字员采纳,获得10
23秒前
猪猪hero发布了新的文献求助10
23秒前
CAOHOU应助林sir采纳,获得10
23秒前
23秒前
甜甜亦巧完成签到,获得积分10
24秒前
栗惠发布了新的文献求助20
25秒前
25秒前
26秒前
28秒前
小二郎应助高手采纳,获得10
28秒前
29秒前
民科王聪发布了新的文献求助10
29秒前
29秒前
YaoZhang完成签到 ,获得积分10
30秒前
潇湘雪月发布了新的文献求助10
31秒前
32秒前
如意枫叶发布了新的文献求助10
32秒前
Rondab应助卡卡罗特采纳,获得10
35秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989242
求助须知:如何正确求助?哪些是违规求助? 3531393
关于积分的说明 11253753
捐赠科研通 3270010
什么是DOI,文献DOI怎么找? 1804868
邀请新用户注册赠送积分活动 882084
科研通“疑难数据库(出版商)”最低求助积分说明 809136