亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Myelin oligodendrocyte glycoprotein-associated disease is associated with BANK1, RNASET2 and TNIP1 polymorphisms

多发性硬化 医学 髓鞘少突胶质细胞糖蛋白 视神经脊髓炎 免疫学 单核苷酸多态性 生物 遗传学 基因型 基因 实验性自身免疫性脑脊髓炎
作者
Yaqing Shu,Xiaoyu Ma,Chen Chen,Yuge Wang,Xiaobo Sun,Liang Zhang,Zhengqi Lu,Frank Petersen,Wei Qiu,Xinhua Yu
出处
期刊:Journal of Neuroimmunology [Elsevier BV]
卷期号:372: 577937-577937 被引量:6
标识
DOI:10.1016/j.jneuroim.2022.577937
摘要

Here we aimed to compare association of common immune-related genetic variants with three autoimmune central nervous system (CNS) demyelinating diseases, namely myelin oligodendrocyte glycoprotein-associated disease (MOGAD), multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD).In this retrospective cross-sectional study, 26 common immune-related single nucleotide polymorphisms were genotyped in 102 patients with MOGAD, 100 patients with MS, 198 patients with NMOSD and 541 healthy control subjects recruited from Guangzhou, China.Among all tested genetic variations, one polymorphism, B cell scaffold protein with ankyrin repeats 1 (BANK1) rs4522865 was associated with multiple disorders, namely MOGAD (OR = 1.94, 95% CI:1.19-3.17, P = 0.0059) and NMOSD (OR = 1.69, 95% CI:1.17-2.45). Besides BANK1 rs4522865, two other non-HLA loci, ribonuclease T2 (RNASET2) rs9355610 (OR = 0.47, 95% CI: 0.26-0.85) and TNFAIP3 interacting protein 1 (TNIP1) rs10036748 (OR = 1.76, 95% CI: 1.16-2.71), were associated with MOGAD. In addition, NMOSD was associated with signal transducer and activator of transcription 4 (STAT4) rs7574865 (OR = 1.58, 95% CI: 1.12-2.24) and general transcription factor Iii (GTF2I) rs73366469 (OR = 1.60, 95% CI:1.12-2.29), while MS was associated with a killer cell lectin like receptor G1 (KLRG1) rs1805673 (OR = 0.61, 95% CI: 0.40-0.94) and T-box transcription factor 21 (TBX21) rs17244587 (OR = 2.25, 95% CI: 1.25-4.06).The current study suggests for the first time three non-HLA susceptibility loci for MOGAD. In addition, comparison of association of 26 immune-related polymorphisms with three autoimmune CNS demyelinating diseases demonstrates substantial difference in genetic basis of those disorders.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
hgsgeospan完成签到,获得积分10
1秒前
直率的笑翠完成签到 ,获得积分10
8秒前
hgs完成签到,获得积分10
13秒前
13秒前
MchemG应助科研通管家采纳,获得10
34秒前
JamesPei应助科研通管家采纳,获得10
34秒前
隐形曼青应助科研通管家采纳,获得10
35秒前
Kevin完成签到,获得积分10
1分钟前
1分钟前
辉哥发布了新的文献求助10
1分钟前
1分钟前
1分钟前
董可以发布了新的文献求助10
1分钟前
英俊的铭应助董可以采纳,获得10
1分钟前
curtain完成签到,获得积分10
2分钟前
大个应助科研通管家采纳,获得10
2分钟前
MchemG应助科研通管家采纳,获得10
2分钟前
所所应助科研通管家采纳,获得10
2分钟前
科研通AI2S应助科研通管家采纳,获得10
2分钟前
2分钟前
落寞书易完成签到 ,获得积分10
2分钟前
2分钟前
现实的小霸王完成签到,获得积分10
2分钟前
3分钟前
Xw完成签到,获得积分10
3分钟前
科研通AI5应助迷人问兰采纳,获得10
3分钟前
Hello应助LSH970829采纳,获得10
3分钟前
Xw发布了新的文献求助10
3分钟前
寒冷的应助核桃采纳,获得30
4分钟前
wen发布了新的文献求助10
4分钟前
隐形曼青应助科研通管家采纳,获得10
4分钟前
科研通AI2S应助科研通管家采纳,获得10
4分钟前
MchemG应助科研通管家采纳,获得10
4分钟前
wen完成签到,获得积分10
4分钟前
4分钟前
4分钟前
4分钟前
yar应助wen采纳,获得10
4分钟前
核桃发布了新的文献求助30
4分钟前
迷人问兰发布了新的文献求助10
4分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990084
求助须知:如何正确求助?哪些是违规求助? 3532108
关于积分的说明 11256447
捐赠科研通 3271016
什么是DOI,文献DOI怎么找? 1805171
邀请新用户注册赠送积分活动 882270
科研通“疑难数据库(出版商)”最低求助积分说明 809228