The Relationship Between Norepinephrine Equivalent Dose of Vasopressors Within 24 Hours From the Onset of Septic Shock and In-Hospital Mortality Rate

The reported mortality rate of septic shock is 30% to 40%. 1 Bauer M. Gerlach H. Vogelmann T. Preissing F. Stiefel J. Adam D. Mortality in sepsis and septic shock in Europe, North America and Australia between 2009 and 2019: results from a systematic review and meta-analysis. Critical Care. 2020; 24: 239 Crossref PubMed Scopus (150) Google Scholar However, these reported mortality rates do not take into consideration the severity of septic shock. There remains limited evidence on the prognosis of patients with septic shock whose condition requires higher doses of vasopressors. Although it is commonly perceived that higher doses of vasopressors translate into worsened clinical outcomes, the complex relationship between vasopressor dose and death has not been well-described. Therefore, we investigated the relationship between cumulative vasopressor dosage and in-hospital mortality rates in patients with septic shock.