离散化
数学
分数阶微积分
最优控制
应用数学
理论(学习稳定性)
操作员(生物学)
数学优化
控制理论(社会学)
数学分析
控制(管理)
计算机科学
机器学习
基因
转录因子
生物化学
人工智能
抑制因子
化学
作者
M. M. Abou Hasan,S. M. AL-Mekhlafi,K. Udhayakumar,F. A. Rihan
标识
DOI:10.1080/02286203.2023.2216621
摘要
This paper investigates the optimal control problem for the tumor-immune system with time-delay in the presence of gene therapy and immuno chemotherapy. Riemann-Liouville fractional order integrals and Caputo fractional order derivatives are combined to form a hybrid fractional order operator. For consistency with the physical model problem, a new parameter ϑ is presented. A stability and bifurcation analysis of the proposed model is performed. The positivity, boundedness, and existence of optimal control for the proposed model are discussed. Grünwald-Letnikov nonstandard finite difference method with the discretization of the hybrid fractional order operator is constructed to solve the proposed model. Examples and comparative studies are presented to demonstrate the simplicity of the approximation approaches and the applicability of the utilized methods.
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