已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Association between admission baseline blood potassium levels and all-cause mortality in patients with acute kidney injury combined with sepsis: A retrospective cohort study

医学 败血症 急性肾损伤 低钾血症 高钾血症 内科学 回顾性队列研究 置信区间 重症监护 重症监护医学
作者
Yifan Guo,Yue Qiu,Taiqi Xue,Pu Yan,Wenjing Zhao,Mengdi Wang,Cheng Liu,Ning Zhang
出处
期刊:PLOS ONE [Public Library of Science]
卷期号:19 (11): e0309764-e0309764
标识
DOI:10.1371/journal.pone.0309764
摘要

Introduction Imbalances in blood potassium (K) homeostasis is a significant contributor to the emergence of severe complications, especially among critically ill patients. Hypokalemia and hyperkalemia are both associated with an increased risk of adverse events. However, it is not known about the impact of blood K levels on risk of intensive care units (ICU) mortality for Acute kidney injury (AKI) combined with sepsis patients. This study aimed to explore the relationship between admission blood K levels and ICU 30-day mortality in patients with AKI combined with sepsis. Methods We selected patients diagnosed with AKI and sepsis on their first ICU admission from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. The first blood K levels within 24 hours of admission were categorized into three groups according to tertiles (T1 < 3.9 mmol/L, 3.9 ≤ T2 < 4.5 mmol/L, and T3 ≥ 4.5 mmol/L), with T2 serving as the reference. We examined the association between blood K levels and ICU 30-day mortality using accelerated failure time (AFT) models and survival analysis. Results A total of 8,242 ICU patients with AKI combined with sepsis were included. In multivariate AFT models, each 1 mmol/L increase in blood K levels was associated with a 13% increase in the risk of ICU 30-day mortality ( p < 0.001, 95% confidence interval (CI): 1.06–1.20). Extended multivariable AFT models showed that, compared to the middle category, patients with high blood K levels (≥ 4.5 mmol/L) were associated with all-cause mortality ( p = 0.002, adjusted hazard ratio (HR) = 1.22, 95% CI: 1.08–1.38), whereas those with low blood K levels (< 3.9 mmol/L) showed no significant difference ( p = 0.385, adjusted HR = 1.06, 95% CI: 0.93–1.21). Kaplan-Meier curves indicated that patients with high blood K levels had higher mortality, and those with middle blood potassium levels (3.9 ≤ K < 4.5 mmol/L) had the lowest mortality. Conclusion The admission baseline blood K levels were significantly associated with ICU 30-day mortality in intensive care patients suffering from AKI in conjunction with sepsis. Therefore, immediate and careful correction of blood potassium imbalances may prove to be a crucial approach in improving outcomes for these patients.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
大学生完成签到 ,获得积分10
1秒前
杨程羽完成签到 ,获得积分10
7秒前
仙女完成签到 ,获得积分10
7秒前
传奇3应助LMX采纳,获得10
8秒前
linghu完成签到 ,获得积分10
10秒前
Tendency完成签到 ,获得积分10
12秒前
善学以致用应助皮皮蟹采纳,获得10
16秒前
16秒前
16秒前
20秒前
小小斌完成签到,获得积分10
20秒前
LMX发布了新的文献求助10
25秒前
28秒前
28秒前
yang完成签到 ,获得积分10
31秒前
沉静安荷给沉静安荷的求助进行了留言
31秒前
皮皮蟹发布了新的文献求助10
32秒前
轻松的惜芹应助科研达人采纳,获得10
34秒前
广州小肥羊完成签到 ,获得积分10
37秒前
皮皮蟹完成签到,获得积分10
41秒前
完美世界应助ceeray23采纳,获得20
46秒前
曾经的电脑完成签到 ,获得积分10
51秒前
Sky完成签到,获得积分10
51秒前
握瑾怀瑜完成签到 ,获得积分0
52秒前
轻松的惜芹应助科研达人采纳,获得10
55秒前
Orange应助高兴的忆曼采纳,获得10
57秒前
平淡访冬完成签到 ,获得积分10
1分钟前
jokerhoney完成签到,获得积分10
1分钟前
李娇完成签到 ,获得积分10
1分钟前
李姝完成签到 ,获得积分10
1分钟前
李昕123完成签到 ,获得积分10
1分钟前
1分钟前
干净涵梅发布了新的文献求助10
1分钟前
星辰大海应助大喵采纳,获得10
1分钟前
CC发布了新的文献求助10
1分钟前
你大米哥完成签到 ,获得积分10
1分钟前
asaki完成签到,获得积分10
1分钟前
瑞瑞刘完成签到 ,获得积分10
1分钟前
freshfire完成签到 ,获得积分10
1分钟前
爱吃大米饭完成签到 ,获得积分10
1分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990012
求助须知:如何正确求助?哪些是违规求助? 3532047
关于积分的说明 11256141
捐赠科研通 3270918
什么是DOI,文献DOI怎么找? 1805105
邀请新用户注册赠送积分活动 882270
科研通“疑难数据库(出版商)”最低求助积分说明 809216