Biogenic selenium nanoparticles: a comprehensive update on the multifaceted application, stability, biocompatibility, risk, and opportunity

Abstract Biogenic selenium nanoparticles (SeNPs) have emerged as promising area of research due to their unique properties and potential multifaceted applications. The biosynthesis of SeNPs through biological methods, such as using microorganism, plant extracts, etc., offers a safe, eco-friendly, and biocompatible approach, compared to traditional chemical synthesis. Recent several studies demonstrated that multifaceted application of SeNPs includes a broad area such as antibacterial, anticancer, antioxidant, antiviral, anti-inflammatory, antidiabetic, and excellent wound healing activity. On the other hand, SeNPs have also shown promising application in sensing of inorganic toxic metals, electrochemistry, agro-industries, aqua-cultures, and in fabrication of solar panels. Additionally, SeNPs capability to enhance the efficacy of traditional antibiotics and act as effective agents against multidrug-resistant pathogens has shown their potential in addressing critical health challenges. Although, the SeNPs exhibit wide applicability, the potential toxicity of Se, particularly in its various oxidative states, necessitates careful assessment of the environmental and health impacts associated with their use. Therefore, understanding the balance between their beneficial properties and potential risks is crucial for its safe applications. This review focuses exclusively on SeNPs synthesized via eco-friendly process, excluding research utilizing other synthesis processes. Moreover, this review aims to offer an overview of the diverse applications, potential risks, stability requirement, and cytocompatibility requirement, and multifaceted opportunities associated with SeNPs. Ultimately, the review bridges a gap in knowledge by providing an updated details of multifaceted applications of SeNPs.