Sex and age distribution of global disease burden of non-rheumatic calcific aortic valve disease from 1990 to 2021.

To analyze sex and age distribution of global disease burden of non-rheumatic calcific aortic valve disease (CAVD) from 1990 to 2021. CAVD data 1990-2021 were obtained from the IHME website for Global Burden of Disease (GBD). The prevalence, mortality, years lived with disability (YLDs), and disability-adjusted life years (DALYs) were analyzed by gender and age groups. Joinpoint regression was used to calculate annual percent change (APC) and average annual percent change (AAPC). In 2021, there were 13.32 million CAVD patients and 142 000 deaths caused by CAVD globally. Age-standardized prevalence was higher in males (193.2/105) than that in females (128.9/105). Patients in 65-85 age group accounted for 64.0% of total cases, while those ≥85 years old accounted for 16.1%. From 1990-2021, prevalence increased in both sexes with an AAPC of 0.72% for males and 0.57% for females, respectively. Prevalence grew fastest from 2000-2010, slowed thereafter, and declined from 2015-2021. In those <65 years old, the mortality of males was 2.4 times higher than that of females, while in those ≥85 years old, mortality of females (117.3/105) exceeded that of males (99.1/105). YLD rates increased with age, and were higher in males for all age groups. DALY rates decreased overall but increased in those ≥85 years old, with a greater increase in females. There are significant gender and age disparities in global disease burden of CAVD, with particular concern for the elderly, especially super-elderly females, indicating the need for personalized intervention strategies.