Regioselective 1,4-Hydroamination of 1,3-Dienes by Photoredox/Cobalt Dual Catalysis

Herein, we report a visible-light-driven and cobalt-mediated 1,4-hydroamination reaction of 1,3-dienes with arylmines as the nucleophiles. The reaction involves regioselective addition of [CoIII]–H to 1,3-diene, followed by oxidation and nucleophilic substitution by amines. Using Ir(ppy)3 as the photocatalyst enables the cobalt redox cycle to be implemented without using an external oxidant and hydride regent. This protocol can be applied as well to forge the carbon–oxygen and carbon–sulfur bonds in an analogous way.