Clinical and Proteomic Risk Profiles of New-Onset Heart Failure in Men and Women

In men and women, the most prominent risk factors for new-onset HF were hypertension and obesity, but they conferred a greater risk of new-onset HF in women. New-onset HF in both men and women was associated with pathophysiological pathways related to neutrophil degranulation and immunomodulation; and these pathways partly mediated the association between hypertension, obesity, and new-onset HF.