Cysteine Peptidases of Calotropis procera (Apocynaceae): A Literature Review on their Biochemical Properties and Potential Applications

白花牛角瓜 夹竹桃科 半胱氨酸 蛋白酵素 生物化学 瑞典全瓷牙 木瓜蛋白酶 生物 化学 植物
作者
Beatriz Leite Nogueira,Flavíana Vieira,Thalles B. Grangeiro
出处
期刊:Current Protein & Peptide Science [Bentham Science Publishers]
卷期号:26
标识
DOI:10.2174/0113892037340497241024095749
摘要

Abstract: The latex of the xerophytic plant Calotropis procera, popularly known as giant milkweed, contains a complex mixture of secondary metabolites and proteins and has attracted the attention of many researchers. Several bioactive laticifer enzymes from C. procera have been studied for their potential applications in the medical, agricultural and food industries. The present work aimed to review the current scientific knowledge on cysteine peptidases from the latex of this plant, highlighting their biochemical properties and possible uses as biotechnological tools. Bibliographic databases (PubMed, Scopus and Web of Science) were searched for scientific works published in the last six decades reporting the purification, biochemical characterization, molecular cloning and potential applications of laticifer cysteine peptidases from C. procera. Since the first works published in the late 1960s on the occurrence of thiol peptidases in this species, five cysteine peptidases (procerain, procerain B, CpCP-1, CpCP-2 and CpCP-3) have been purified and biochemically characterized. The characterized enzymes are members of the subfamily C1A of sulfhydryl proteases, showing the characteristic biochemical and structural features of papain and related proteins. Several biological activities of the purified enzymes have been demonstrated, including the inhibition of phytopathogenic fungi and milk coagulation properties, which may be of practical use. Moreover, pharmacologically active propeptides released from the posttranslational processing of C. procera cysteine peptidase zymogens have been shown to be promising therapeutic agents against cancer cells. Further research is needed to provide a better comprehensive understanding of the mode of action and biosafety of these molecules.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
ZERO完成签到,获得积分10
1秒前
ssssxr完成签到,获得积分20
2秒前
Neko发布了新的文献求助10
3秒前
3秒前
酸奶辣条发布了新的文献求助10
3秒前
8秒前
CodeCraft应助博修采纳,获得10
11秒前
11秒前
xu完成签到 ,获得积分10
11秒前
领导范儿应助PXP采纳,获得10
13秒前
欧阳正义发布了新的文献求助10
16秒前
16秒前
深情安青应助夔kk采纳,获得30
17秒前
xzzt发布了新的文献求助10
17秒前
18秒前
19秒前
安白完成签到 ,获得积分20
21秒前
hoshi发布了新的文献求助10
21秒前
我陈雯雯实名上网完成签到,获得积分10
21秒前
22秒前
PXP发布了新的文献求助10
25秒前
26秒前
27秒前
28秒前
博修发布了新的文献求助10
30秒前
芒芒发布了新的文献求助200
31秒前
31秒前
烟花应助飞天817采纳,获得10
31秒前
31秒前
饱满的书萱完成签到,获得积分20
32秒前
35秒前
李健应助博修采纳,获得10
35秒前
36秒前
李健应助刘先生采纳,获得10
36秒前
37秒前
38秒前
wanci应助Shennnn采纳,获得10
38秒前
39秒前
岳阳张震岳完成签到,获得积分10
39秒前
40秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3967279
求助须知:如何正确求助?哪些是违规求助? 3512575
关于积分的说明 11164253
捐赠科研通 3247522
什么是DOI,文献DOI怎么找? 1793850
邀请新用户注册赠送积分活动 874729
科研通“疑难数据库(出版商)”最低求助积分说明 804495