Importance of method assumptions: Response to “Challenges in undertaking nonlinear Mendelian randomization”

ObesityEarly View LETTER TO THE EDITOR Importance of method assumptions: Response to "Challenges in undertaking nonlinear Mendelian randomization" This article relates to: Response to "Importance of method assumptions" Kaitlin H. Wade, Nicholas J. Timpson, Fergus W. Hamilton, Naveed Sattar, David Carslake, George Davey Smith, Obesity First Published online: May 21, 2024 C. Mary Schooling, Corresponding Author C. Mary Schooling [email protected] orcid.org/0000-0001-9933-5887 City University of New York, Graduate School of Public Health and Health Policy, New York, New York, USA School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China Correspondence C. Mary Schooling, City University of New York, Graduate School of Public Health and Health Policy, 55 W 125th St, New York, NY 10027, USA. Email: [email protected]Search for more papers by this authorGuoyi Yang, Guoyi Yang orcid.org/0000-0002-4387-386X School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, ChinaSearch for more papers by this author C. Mary Schooling, Corresponding Author C. Mary Schooling [email protected] orcid.org/0000-0001-9933-5887 City University of New York, Graduate School of Public Health and Health Policy, New York, New York, USA School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China Correspondence C. Mary Schooling, City University of New York, Graduate School of Public Health and Health Policy, 55 W 125th St, New York, NY 10027, USA. Email: [email protected]Search for more papers by this authorGuoyi Yang, Guoyi Yang orcid.org/0000-0002-4387-386X School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, ChinaSearch for more papers by this author First published: 21 May 2024 https://doi.org/10.1002/oby.24055Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. REFERENCES 1Wade KH, Hamilton FW, Carslake D, Sattar N, Davey Smith G, Timpson NJ. Challenges in undertaking nonlinear Mendelian randomization. Obesity (Silver Spring). 2023; 31: 2887-2890. 10.1002/oby.23927 PubMedGoogle Scholar 2Wade KH, Carslake D, Sattar N, Davey Smith G, Timpson NJ. BMI and mortality in UK Biobank: revised estimates using Mendelian randomization. Obesity (Silver Spring). 2018; 26: 1796-1806. 10.1002/oby.22313 CASPubMedWeb of Science®Google Scholar 3Small DS. Commentary: interpretation and sensitivity analysis for the localized average causal effect curve. Epidemiology. 2014; 25: 886-888. 10.1097/EDE.0000000000000187 PubMedWeb of Science®Google Scholar 4Bareinboim E, Pearl J. Causal inference and the data-fusion problem. Proc Natl Acad Sci U S A. 2016; 113: 7345-7352. 10.1073/pnas.1510507113 CASPubMedWeb of Science®Google Scholar 5Sanderson E, Glymour MM, Holmes MV, et al. Mendelian randomization. Nat Rev Methods Primers. 2022; 2: 6. 10.1038/s43586-021-00092-5 CASPubMedGoogle Scholar 6Lewis SJ, Brunner EJ. Methodological problems in genetic association studies of longevity–the apolipoprotein E gene as an example. Int J Epidemiol. 2004; 33: 962-970. 10.1093/ije/dyh214 PubMedWeb of Science®Google Scholar 7Burgess S. Violation of the constant genetic effect assumption can result in biased estimates for non-linear Mendelian randomization. Hum Hered. 2023; 88: 79-90. 10.1159/000531659 CASPubMedGoogle Scholar 8Linares C, Su D. Body mass index and health among Union Army veterans: 1891–1905. Econ Hum Biol. 2005; 3: 367-387. 10.1016/j.ehb.2005.06.002 PubMedGoogle Scholar Early ViewOnline Version of Record before inclusion in an issue ReferencesRelatedInformation