Regioselective and Diastereoselective Decarboxylative Allylic (Amino)Ketalization of Dihydropyranone Derivatives

It remains a challenge to achieve regioselectivity and stereoselectivity in the synthesis of dihydropyranone derivatives. Herein, an Ir/Pd‐catalyzed decarboxylative allylic (amino)ketalization was disclosed to prepare dihydropyranone derivatives in regio‐ and diastereoselectivities under mild conditions, resulting in O‐ and N‐allylative products. It provided a strategy for the post‐modifications of dihydropyranone derivatives.