犬尿氨酸
巴比妥酸
芳香烃受体
犬尿氨酸途径
外周血单个核细胞
免疫系统
炎症
内生
医学
内科学
免疫学
化学
内分泌学
受体
药理学
色氨酸
敌手
生物化学
转录因子
体外
氨基酸
基因
作者
Niklas Joisten,David Walzik,Alexander Schenk,Alan J. Metcalfe,Sergen Belen,Kirill Schaaf,Daniel Jacko,Sebastian Gehlert,Polyxeni Spiliopoulou,Ann‐Marie Garzinsky,Mario Thevis,Ludwig Rappelt,Lars Donath,Sven G. Meuth,Wilhelm Bloch,Philipp Zimmer
出处
期刊:American Journal of Physiology-cell Physiology
[American Physiological Society]
日期:2024-06-24
被引量:1
标识
DOI:10.1152/ajpcell.00282.2024
摘要
The kynurenine pathway of tryptophan degradation generates several metabolites such as kynurenine or kynurenic acid that serve as endogenous ligands of the aryl hydrocarbon receptor (AHR). Due to its distinct biological roles particularly modulating the immune system, the AHR is a current therapeutic target across different inflammation-related diseases. Here, we show an acute exercise-induced increase in AHR ligand availability on a systemic level and a kynurenine pathway activation in peripheral blood mononuclear cells (PBMCs). Concurrently, the AHR is activated in PBMCs following acute exercise. Exercise effects on both, kynurenic acid and AHR activation in PBMCs were greater in response to high-intensity interval exercise (50 min., six three-minute intervals á 90% V̇O 2peak , and three-minute intervals at 50% V̇O 2peak in between) compared to workload-matched moderate intensity continuous exercise (50 min.). In conclusion, these data indicate a novel mechanistic link how exercise modulates the immune system through the kynurenine pathway-AHR axis, potentially underlying exercise-induced benefits in various chronic diseases.
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