免疫系统
癌症
癌细胞
生物
免疫学
癌症疫苗
癌症研究
免疫疗法
遗传学
作者
João Pessoa,Sandrina Nóbrega‐Pereira,Bruno Bernardes de Jesus
出处
期刊:Aging
[Impact Journals LLC]
日期:2024-06-26
卷期号:16 (12): 10657-10665
被引量:1
标识
DOI:10.18632/aging.205975
摘要
Two recent seminal works have untangled the intricate role of tumor-associated senescent cells in cancer progression, or regression, by guiding our immune system against cancer cells. The characterization of these unique, yet diverse cell populations, should be considered, particularly when contemplating the use of senolytics, which are drugs that selectively eliminate senescent cells, in a cancer framework. Here, we will describe the current knowledge in this field. In particular, we will discuss how the presence of senescent cells in tumors could be used as a therapeutic target in immunogenic cancers and how we may hypothetically design an adaptive anti-aging vaccine.
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