壳聚糖
生物相容性
纳米复合材料
荧光
聚合物
材料科学
化学工程
纳米技术
自愈水凝胶
化学
高分子化学
复合材料
有机化学
物理
工程类
量子力学
冶金
作者
Yu Lan Tong,Kuan Yang,Wei Wei,Li Ting Gao,Peng Cheng Li,Xin Zhao,Yongmei Chen,Jianhui Li,Haopeng Li,Hideyuki Miyatake,Yoshihiro Ito
标识
DOI:10.1016/j.carbpol.2024.122203
摘要
Red fluorescent hydrogels possessing injectable and self-healing properties have widespread potential in biomedical field. It is still a challenge to achieve a biomacromolecules based dynamic hydrogels simultaneously combining with excellent red fluorescence, good mechanical properties, and biocompatibility. Here we firstly exploited hydrophilic inclusion complex of (R-CDs@α-CD) derived from red fluorescent carbon dots (R-CDs) and α-cyclodextrin (α-CD), and then achieved a red fluorescent and dynamic polysaccharide R-CDs@α-CD/CEC-l-OSA hydrogel. The nanocomposite hydrogel can be fabricated through controlling dopant of red fluorescent R-CDs@α-CD into dynamic polymer networks, taking dynamic crosslinked N-carboxyethyl chitosan (CEC) and oxidized sodium alginate (OSA) as an example. The versatile hydrogel simultaneously combines the features of injection, biocompatibility, and augmented mechanical properties and self-healing behavior, especially in rapid self-recovery even after integration. The R-CDs@α-CD uniformly dispersed into dynamic hydrogel played the role of killing two birds with one stone, that is, endowing red fluorescence as a hydrophilic fluorescent substance, and improving mechanical and self-healing properties as a dynamic nano-crosslinker, via providing hydrogen bonds as reversible crosslinkings. The novel red fluorescent and dynamic hydrogel based on polysaccharides hold promise for using as biomaterials in biomedical field.
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