肿瘤微环境
CD8型
癌症研究
免疫系统
HIF1A型
三氯化碳
缺氧(环境)
趋化因子
生物
T细胞
免疫学
化学
血管生成
四氯化碳
有机化学
氧气
作者
Yuan Liang,Qingfa Bu,Wenhua You,Rui Zhang,Zibo Xu,Xiaojie Gan,Jinren Zhou,Lei Qiao,Tianning Huang,Ling Lü
标识
DOI:10.1016/j.bbadis.2024.167276
摘要
The role of hypoxia in the tumor microenvironment of intrahepatic cholangiocarcinoma (iCCA) remains unclear. Here, we generated a comprehensive atlas of the entire tumor microenvironment and delineated the multifaceted cell-cell interactions to decipher hypoxia-induced pro-tumor immune suppression. We discovered hypoxia is significantly associated with iCCA progression via the activation of HIF1A expression. Moreover, hypoxia-dependent PPARγ-mediated fatty acid oxidation in APOE
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