生物
轮状病毒
重组DNA
病毒学
免疫
佐剂
轮状病毒疫苗
微生物学
免疫
蛋白质亚单位
腹泻
免疫学
抗原
免疫系统
病毒
基因
医学
生物化学
内科学
作者
Sufen Li,Xuechao Tang,Jinzhu Zhou,Xianyu Bian,Jianxin Wang,Laqiang Gu,Xuejiao Zhu,Ran Tao,Min Sun,Xuehan Zhang,Bin Li
出处
期刊:Virology
[Elsevier]
日期:2024-06-05
卷期号:597: 110130-110130
标识
DOI:10.1016/j.virol.2024.110130
摘要
Porcine rotavirus (PoRV) is one of the main pathogens causing diarrhea in piglets, and multiple genotypes coexist. However, an effective vaccine is currently lacking. Here, the potential adjuvant of nonstructural protein 4 (NSP4) and highly immunogenic structural protein VP4 prompted us to construct recombinant NSP486-175aa (NSP4*) and VP426-476aa (VP4*) proteins, combine them as immunogens to evaluate their efficacy. Results indicated that NSP4* enhanced systemic and local mucosal responses induced by VP4*. The VP4*-IgG, VP4*-IgA in feces and IgA-secreting cells in intestines induced by the co-immunization were significantly higher than those induced by VP4* alone. Co-immunization of NSP4* and VP4* also induced strong cellular immunity with significantly increased IFN-λ than the single VP4*. Summarily, the NSP4* as a synergistical antigen exerted limited effects on the PoRV NAbs elevation, but conferred strong VP4*-specific mucosal and cellular efficacy, which lays the foundation for the development of a more effective porcine rotavirus subunit vaccine.
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