Enhanced thyroid nodule segmentation through U-Net and VGG16 fusion with feature engineering: A comprehensive study

The thyroid gland, a key component of the endocrine system, is pivotal in regulating bodily functions. Thermography, a non-invasive imaging technique utilizing infrared cameras, has emerged as a diagnostic tool for thyroid-related conditions, offering advantages such as early detection and risk stratification. Artificial intelligence (AI) has demonstrated success in medical diagnostics, and its integration into thermal imaging analysis holds promise for improving diagnostic capabilities. This study aims to explore the potential of AI, specifically convolutional neural networks (CNNs), in enhancing the analysis of thyroid thermograms for the detection of nodules and abnormalities. Artificial intelligence (AI) and machine learning techniques are integrated to enhance thyroid thermal image analysis. Specifically, a fusion of U-Net and VGG16, combined with feature engineering (FE), is proposed for accurate thyroid nodule segmentation. The novelty of this research lies in leveraging feature engineering in transfer learning for the segmentation of thyroid nodules, even in the presence of a limited dataset. The study presents results from four conducted studies, demonstrating the efficacy of this approach even with a limited dataset. It's observed that in study 4, using FE has led to a significant improvement in the value of the dice coefficient. Even for the small size of the masked region, incorporating radiomics with FE resulted in significant improvements in the segmentation dice coefficient. It's promising that one can achieve higher dice coefficients by employing different models and refining them. The findings here underscore the potential of AI for precise and efficient segmentation of thyroid nodules, paving the way for improved thyroid health assessment.