Dectin‐1 induces TRPV1 sensitization and contributes to visceral hypersensitivity of irritable bowel syndrome in male mice

This work provides direct evidence for the functional regulation of TRPV1 channel by Dectin-1 activity, proposing a new mechanism underlying TRPV1 sensitization. Control of intestinal fungi might be beneficial for the treatment of refractory abdominal pain in patients with IBS or IBD in remission.