溶酶体
内质网
细胞生物学
钙
高尔基体
钙信号传导
第二信使系统
细胞内
细胞外
线粒体
程序性细胞死亡
生物学中的钙
化学
生物
生物化学
细胞凋亡
酶
有机化学
作者
Mateus Milani,Philippe Pihán,Claudio Hetz
出处
期刊:Cell Calcium
[Elsevier]
日期:2023-05-05
卷期号:113: 102751-102751
被引量:11
标识
DOI:10.1016/j.ceca.2023.102751
摘要
Calcium is a crucial messenger of intracellular and extracellular signals, regulating a great variety of cellular processes such as cell death, proliferation, and metabolism. Inside the cell, calcium signaling is one of the main interorganelle communication mediators, with central functional roles at the endoplasmic reticulum (ER), mitochondria, Golgi complex, and lysosomes. Lysosomal function is highly dependent on lumenal calcium and most of the lysosomal membrane-localised ion channels regulate several lysosomal functions and properties such as lumenal pH. One of these functions configures a specific type of cell death involving lysosomes, named lysosome-dependent cell death (LDCD), which contributes to maintenance of tissue homeostasis, development and pathology when deregulated. Here, we cover the fundamental aspects of LDCD with a special focus on recent advances in calcium signaling in LDCD.
科研通智能强力驱动
Strongly Powered by AbleSci AI