嗜酸性粒细胞
趋化因子
趋化性
炎症
嗜酸性
免疫学
嗜酸性粒细胞增多症
气道
化学
医学
哮喘
生物化学
病理
受体
外科
作者
Maureen Yin,Ridhima Wadhwa,Jacqueline E. Marshall,Caitlin M. Gillis,Richard Kim,Kamal Dua,Eva M. Pålsson‐McDermott,Padraic G. Fallon,Philip M. Hansbro,Luke A.J. O'Neill
出处
期刊:Journal of Immunology
[The American Association of Immunologists]
日期:2023-11-22
卷期号:212 (1): 13-23
被引量:1
标识
DOI:10.4049/jimmunol.2300155
摘要
4-Octyl itaconate (4-OI) is a derivative of the Krebs cycle-derived metabolite itaconate and displays an array of antimicrobial and anti-inflammatory properties through modifying cysteine residues within protein targets. We have found that 4-OI significantly reduces the production of eosinophil-targeted chemokines in a variety of cell types, including M1 and M2 macrophages, Th2 cells, and A549 respiratory epithelial cells. Notably, the suppression of these chemokines in M1 macrophages was found to be NRF2-dependent. In addition, 4-OI can interfere with IL-5 signaling and directly affect eosinophil differentiation. In a model of eosinophilic airway inflammation in BALB/c mice, 4-OI alleviated airway resistance and reduced eosinophil recruitment to the lungs. Our findings suggest that itaconate derivatives could be promising therapeutic agents for the treatment of eosinophilic asthma.
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