Postbiotics: An alternative and innovative intervention for the therapy of inflammatory bowel disease

失调 免疫系统 微生物群 炎症性肠病 肠道菌群 医学 疾病 胃肠道 生物 微生物学 免疫学 生物信息学 内科学
作者
Kavita Kavita,Hari Om,Umesh Chand,Pramod Kumar Kushawaha
出处
期刊:Microbiological Research [Elsevier]
卷期号:279: 127550-127550 被引量:8
标识
DOI:10.1016/j.micres.2023.127550
摘要

Inflammatory Bowel Disease (IBD) is a persistent gastrointestinal (GI) tract inflammatory disease characterized by downregulated mucosal immune activities and a disrupted microbiota environment in the intestinal lumen. The involvement of bacterium postbiotics as mediators between the immune system and gut microbiome could be critical in determining why host-microbial relationships are disrupted in IBD. Postbiotics including Short-chain fatty acids (SCFAs), Organic acids, Proteins, Vitamins, Bacteriocins, and Tryptophan (Trp) are beneficial bioactive compounds formed via commensal microbiota in the gut environment during the fermentation process that can be used to improve consumer health. The use of metabolites or fragments from microorganisms can be a very attractive treatment and prevention technique in modern medicine. Postbiotics are essential in the immune system's development since they alter the barrier tightness, and the gut ecology and indirectly shape the microbiota's structure. As a result, postbiotics may be beneficial in treating or preventing various diseases, even some for which there is no effective causative medication. Postbiotics may be a promising tool for the treatment of IBD in individuals of all ages, genders, and even geographical locations. Direct distribution of postbiotics may provide a new frontier in microbiome-based therapy for IBD since it allows both the management of host homeostasis and the correction of the negative implications of dysbiosis. Further studies of the biological effects of these metabolites are expected to reveal innovative applications in medicine and beyond. This review attempts to explore the possible postbiotic-based interventions for the treatment of IBD.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
脑三问发布了新的文献求助10
1秒前
1秒前
共享精神应助义气的羽毛采纳,获得10
1秒前
1秒前
紫紫完成签到,获得积分10
2秒前
香锅不要辣完成签到 ,获得积分10
2秒前
自然紫山完成签到,获得积分10
3秒前
zyh完成签到,获得积分10
3秒前
4秒前
斯文败类应助vic采纳,获得10
5秒前
12秒前
素和姣姣完成签到,获得积分10
14秒前
shinhee完成签到,获得积分10
15秒前
思源应助GEZI采纳,获得10
16秒前
打打应助追寻南珍采纳,获得30
17秒前
zxzx关注了科研通微信公众号
17秒前
调研昵称发布了新的文献求助10
17秒前
17秒前
gluwater完成签到,获得积分20
18秒前
19秒前
万能图书馆应助ddd采纳,获得30
20秒前
小女子常戚戚完成签到,获得积分10
23秒前
等等完成签到,获得积分20
23秒前
vic发布了新的文献求助10
25秒前
Akim应助戴先森采纳,获得10
26秒前
27秒前
28秒前
小十发布了新的文献求助10
28秒前
丘比特应助等等采纳,获得30
30秒前
蒙圈完成签到 ,获得积分10
32秒前
zxzx发布了新的文献求助10
33秒前
hy完成签到,获得积分10
33秒前
34秒前
GEZI发布了新的文献求助10
34秒前
34秒前
天上的云在偷偷看你完成签到,获得积分10
36秒前
37秒前
39秒前
gluwater发布了新的文献求助20
41秒前
戴先森发布了新的文献求助10
43秒前
高分求助中
The ACS Guide to Scholarly Communication 2500
Sustainability in Tides Chemistry 2000
Studien zur Ideengeschichte der Gesetzgebung 1000
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Threaded Harmony: A Sustainable Approach to Fashion 810
Pharmacogenomics: Applications to Patient Care, Third Edition 800
Genera Insectorum: Mantodea, Fam. Mantidæ, Subfam. Hymenopodinæ (Classic Reprint) 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3082549
求助须知:如何正确求助?哪些是违规求助? 2735847
关于积分的说明 7539036
捐赠科研通 2385432
什么是DOI,文献DOI怎么找? 1264844
科研通“疑难数据库(出版商)”最低求助积分说明 612830
版权声明 597685