间质细胞
脂肪生成
免疫系统
过氧化物酶体增殖物激活受体
炎症
内科学
内分泌学
骨髓
受体
脾脏
体外
敌手
生物
医学
免疫学
脂肪组织
生物化学
作者
Xing Shi,Kai Ding,Raysa Rosario,Ashwin Ajith,Yun Su,Seán Shaw,ML Lawrence,Xin‐Yun Lu,Anatolij Horuzsko,Carlos M. Isales
出处
期刊:The Journals of Gerontology
[Oxford University Press]
日期:2023-10-19
标识
DOI:10.1093/gerona/glad247
摘要
This study investigates the effects of peroxisome proliferator-activated receptor gamma (PPARγ) inhibition on bone and immune cell profiles in aged female mice, as well as in vitro stromal stem cell osteogenic differentiation and inflammation gene expression. The hypothesis was that inhibition of PPARγ would increase bone mass and alter immune and other cellular functions. Our results showed that treatment with PPARγ antagonist GW9662 for 6 weeks reduced bone volume and trabecular number and increased trabecular spacing. However, inhibition of PPARγ had no significant effect on marrow and spleen immune cell composition in aged female mice. In vitro experiments indicated that GW9662 treatment increased the expression of osteogenic genes but did not affect adipogenic genes. Additionally, GW9662 treatment decreased the expression of several inflammation-related genes. Overall, these findings suggest that PPARγ inhibition may have adverse effects on bone in aged female mice.
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