上睑下垂
坏死性下垂
医学
狼疮性肾炎
肾脏疾病
肾病
急性肾损伤
肾
疾病
死因
免疫学
程序性细胞死亡
人口
炎症
炎症体
病理
内科学
细胞凋亡
生物
内分泌学
糖尿病
环境卫生
生物化学
作者
Boyan Hu,Kuai Ma,Wei Wang,Zhongyu Han,Mingxuan Chi,Moussa Ide Nasser,Chi Liu
标识
DOI:10.2174/0109298673255656231003111621
摘要
Kidney diseases, particularly Acute Kidney Injury (AKI) and Chronic Kidney Disease (CKD), are identified as global public health issues affecting millions of individuals. In addition, the frequency of renal diseases in the population has increased dramatically and rapidly in recent years. Renal disorders have become a significant public health burden. The pathophysiology of renal diseases is significantly connected with renal cell death, including apoptosis, necrosis, necroptosis, ferroptosis, pyroptosis, and autophagy, as is now recognized. Unlike other forms of cell death, pyroptosis is a unique planned cell death (PCD). Scientists have proven that pyroptosis is crucial in developing various disorders, and this phenomenon is gaining increasing attention. It is considered a novel method of inflammatory cell death. Intriguingly, inflammation is among the most significant pathological characteristics of renal disease. This study investigates the effects of pyroptosis on Acute Kidney Injury (AKI), Chronic Kidney Disease (CKD), Diabetic Nephropathy (DN), Immunoglobulin A (IgA) Nephropathy, and Lupus Nephritis (LN) to identify novel therapeutic targets for kidney diseases.
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