化学
HDAC6型
异羟肟酸
体外
对接（动物）
广谱
黑色素瘤
IC50型
HDAC8型
组蛋白脱乙酰基酶
细胞培养
药理学
结构-活动关系
立体化学
生物化学
癌症研究
组蛋白
组合化学
生物
基因
医学
遗传学
护理部
作者
Xin Chen,Jiayun Wang,Peng Zhao,Baiyun Dang,Ting Liang,Raphael R. Steimbach,Aubry K. Miller,Jia Liu,Xin Wang,Tongtong Zhang,Xiaofa Luan,Jiadong Hu,Jin‐Ming Gao
标识
DOI：10.1016/j.ejmech.2023.115776
摘要
A series of tetrahydro-β-carboline (THβC)-based hydroxamic acids were rationally designed and synthesized as novel selective HDAC6 inhibitors (sHDAC6is) by the application of scaffold hopping strategy. Several THβC analogues were highly potent (IC
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