Novel cardiovascular protective effects of RhoA signaling and its therapeutic implications

罗亚 应力纤维 小型GTPase 细胞生物学 信号转导 肌动蛋白细胞骨架 生物 调节器 肌动蛋白 转录因子 细胞信号 GTP酶 细胞骨架 细胞 基因 生物化学 焦点粘着
作者
Joanne Ern Chi Soh,Akio Shimizu,Akira Sato,Hisakazu Ogita
出处
期刊:Biochemical Pharmacology [Elsevier BV]
卷期号:218: 115899-115899 被引量:4
标识
DOI:10.1016/j.bcp.2023.115899
摘要

Ras homolog gene family member A (RhoA) belongs to the Rho GTPase superfamily, which was first studied in cancers as one of the essential regulators controlling cellular function. RhoA has long attracted attention as a key molecule involved in cell signaling and gene transcription, through which it affects cellular processes. A series of studies have demonstrated that RhoA plays crucial roles under both physiological states and pathological conditions in cardiovascular diseases. RhoA has been identified as an important regulator in cardiac remodeling by regulating actin stress fiber dynamics and cytoskeleton formation. However, its underlying mechanisms remain poorly understood, preventing definitive conclusions being drawn about its protective role in the cardiovascular system. In this review, we outline the characteristics of RhoA and its related signaling molecules, and present an overview of RhoA classical function and the corresponding cellular responses of RhoA under physiological and pathological conditions. Overall, we provide an update on the novel signaling under RhoA in the cardiovascular system and its potential clinical and therapeutic targets in cardiovascular medicine.
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