The Association Between Remnant Cholesterol and Blood Pressure: National Health and Nutrition Examination Surveys 2013-2018

Remnant cholesterol (RC) is cholesterol derived from chylomicron remnants, very low–density lipoproteins and remnants, and intermediate-density lipoproteins. RC is capable of entering the subendothelial space, leading to endothelial dysfunction and vascular injury without oxidization, as required by low-density lipoprotein cholesterol (LDL-C). 1 Sandesara PB Virani SS Fazio S Shapiro MD The forgotten lipids: triglycerides, remnant cholesterol, and atherosclerotic cardiovascular disease risk. Endocr Rev. 2019; 40: 537-557 Crossref PubMed Scopus (224) Google Scholar Recent observational data have suggested that RC may increase the risk of hypertension. 2 Chen MM Huang X Xu C Song XH Liu YM Yao D Lu H Wang G Zhang GL Chen Z Sun T Yang C Lei F Qin JJ Ji YX Zhang P Zhang XJ Zhu L Cai J Wan F She ZG Li H High remnant cholesterol level potentiates the development of hypertension. Front Endocrinol. 2022; 13830347 Google Scholar Using a nationally representative cohort, we assessed the association between RC and hypertension and blood pressure (BP) control and systolic BP (SBP) and diastolic BP (DBP) in adults with hypertension.