Gaining a comprehensive understanding of the risk factors, devising efficacious therapies, and tackling the methodological obstacles inherent in investigating the cognitive consequences of obesity are imperative undertakings in both clinical and research contexts. The complex interaction between metabolic, inflammatory, and lifestyle factors highlights the necessity of adopting a holistic strategy to address cognitive impairments in patients with obesity. The resolution of methodological obstacles, including ethical concerns and the identification of suitable evaluation instruments, is crucial for the progression of our understanding in this domain and the enhancement of cognitive well-being among individuals impacted by obesity.