Diagnostic value of FibroTouch in identifying hepatic steatosis in NAFLD with MRI‐PDFF as the reference standard

医学 非酒精性脂肪肝 脂肪变性 接收机工作特性 磁共振成像 腰围 置信区间 脂肪肝 内科学 混淆 神经组阅片室 核医学 胃肠病学 体质指数 放射科 疾病 神经学 精神科
作者
Rong Mu,You Chen Xia,Kou Yun Zhu,Jing Lu,Qian Luo,Lei Zhang,Ren Kun Lin,Xiao Bo Cai,Ying Qu,Lun Gen Lu
出处
期刊:Journal of Digestive Diseases [Wiley]
卷期号:24 (12): 691-701 被引量:1
标识
DOI:10.1111/1751-2980.13242
摘要

Objective To estimate the performance of the FibroTouch‐based ultrasound attenuation parameter (UAP) for assessing hepatic steatosis in nonalcoholic fatty liver disease (NAFLD), with magnetic resonance imaging proton density fat fraction (MRI‐PDFF) as the reference standard. Methods This prospective, cross‐sectional study included 275 individuals in the training group and 110 individuals in the validation group, all of whom completed a standardized research visit, laboratory tests, MRI‐PDFF, and UAP measurements over 1 month. Pearson correlation coefficient and Bland–Altman analysis were used to assess the agreement between UAP and MRI‐PDFF for the detection of hepatic steatosis. The diagnostic value of UAP was evaluated by the area under the receiver operating characteristic (ROC) curve (AUROC). Confounding factors to UAP performance were identified by ROC curves and regression analyses. Results The AUROC of UAP for detecting MRI‐PDFF at ≥5%, ≥10%, and ≥20% were 0.95 (95% confidence interval [CI] 0.92–0.97), 0.86 (95% CI 0.81–0.90), and 0.90 (95% CI 0.86–0.93), respectively, and their optimal thresholds were 259, 274, and 295 dB/m, respectively. The UAP measurements had higher diagnostic accuracy in participants with lower waist circumference (≤90 cm for men and ≤80 cm for women) compared to those with higher waist circumference (AUROC values: 0.97 vs 0.84, P < 0.05). Bland–Altman analysis showed good agreement between UAP and MRI‐PDFF (bias 0.00021). According to established regression analyses, hepatic steatosis could be accurately diagnosed using UAP estimation. Conclusions FibroTouch‐UAP has a high diagnostic potential for hepatic steatosis in NAFLD patients and helps clinical assessment and monitoring.
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