Slide-type waveflex biosensor based on signal enhancement technology for alpha-fetoprotein detection

生物传感器 材料科学 阿尔法(金融) 信号(编程语言) 纳米技术 光学 计算机科学 医学 物理 结构效度 护理部 程序设计语言 患者满意度
作者
Guoru Li,Xiangshan Li,Ragini Singh,Guiwei Zhang,Bingyuan Zhang,Santosh Kumar
出处
期刊:Optics Letters [Optica Publishing Group]
卷期号:48 (18): 4745-4745 被引量:12
标识
DOI:10.1364/ol.501864
摘要

The development of signal enhancement technology in optical fiber biosensors is beneficial for the accurate measurement of low-concentration samples. Here, a localized surface plasmon resonance (LSPR)-based fiber biosensor combining a slide-type fiber structure (thus named WaveFlex Biosensor) and low-dimensional materials is proposed for alpha-fetoprotein (AFP) detection. A symmetric transverse offset splicing technology was used to fabricate the multi-mode fiber (MMF-multi-core fiber (MCF)-MMF structure. Furthermore, the MMF on one side was prepared into an S-taper, forming a slide-type fiber structure to generate more energy leakage. The LSPR signal generated by gold nanoparticles (AuNPs) was enhanced by the CeO2 NPs and C3N quantum dots functionalized on the fiber probe. The excellent performance of NPs was conducive to improving the sensitivity of the WaveFlex biosensor and enabling the rapid detection of samples. An AFP antibody was used to identify AFP micro-biomolecules in a specific manner. Based on the combination of the above two methods, the developed fiber probe was applied to detect AFP, and the sensitivity and limit of detection were 32 pm/(ng/mL) and 6.65 ng/mL, respectively. The experimental results demonstrate that the signal-enhanced AFP WaveFlex biosensor has great potential for the rapid and accurate detection of AFP.
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