Primary Balloon Angioplasty versus Hydrostatic Dilation for Arteriovenous Fistula Creation in Patients with Small-Caliber Cephalic Veins: A Systematic Review and Meta-analysis

Abstract

Objectives

For arteriovenous fistula (AVF) presence of a venous segment with adequate diameter is essential which is lacking in many patients. To find the optimal augmentation technique in patients with small-caliber cephalic vein (i.e., cephalic vein diameter < 3mm), studies compared primary balloon angioplasty (PBA) versus hydrostatic dilation (HD); however, remained debatable. This systematic review seeks to determine which technique is preferable.

Methods

We searched Medline, PubMed, Embase, and Google Scholar. Primary outcomes were 6-month primary patency, reintervention, and working AVF. Secondary outcomes were immediate success, the AVF's maturation time (day), and surgical site infection.

Results

Three randomized controlled trials yielding 180 patients were included, of which 89 patients were in the PBA group. The odds ratio (OR) of primary patency was significantly higher in the PBA group (OR, 6.09; 95% CI, 2.36-15.76; p=0.0002), the OR of reintervention was significantly lower in the PBA group (OR, 0.16; 95% CI, 0.06-0.42; P=0.0002), and the OR of working AVF was greater in PBA group (OR, 4.22; 95% CI, 1.31-13.59; P=0.02). The OR of immediate success was significantly greater in the PBA group (OR, 11.42; 95% CI, 2.54-51.42; P=0.002), and the AVF maturation time was significantly shorter in patients who underwent PBA (MD, -20.32 day; 95% CI, -30.12 to -10.52; P=0.0001). The certainty of the evidence was high.

Conclusion

PBA of small cephalic veins with diameter ≤2.5 cm is a safe, feasible, and efficacious augmentation method for AVF creation. This technique achieves favorable maturation outcomes, and PBA is superior to the standard hydrostatic dilatation technique.