农奴
mdx鼠标
杜氏肌营养不良
心室
内科学
内分泌学
化学
医学
ATP酶
解剖
肌营养不良蛋白
生物化学
酶
作者
Riley Cleverdon,Jessica Braun,Mia S. Geromella,Kennedy C Whitley,Daniel Markó,Sophie I. Hamstra,Brian D. Roy,Rebecca E. K. MacPherson,Val A. Fajardo
出处
期刊:iScience
[Cell Press]
日期:2022-09-01
卷期号:25 (9): 104972-104972
被引量:4
标识
DOI:10.1016/j.isci.2022.104972
摘要
The DBA/2J (D2) mdx mouse is a more severe model of Duchenne muscular dystrophy when compared to the traditional C57BL/10 (C57) mdx mouse. Here, we questioned whether sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) function would differ in muscles from young D2 and C57 mdx mice. Both D2 and C57 mdx mice exhibited signs of impaired Ca2+ uptake in the gastrocnemius, diaphragm, and left ventricle; however, the level of impairment was more severe in D2 mdx mice. Reductions in maximal SERCA activity were also more prominent in the D2 mdx gastrocnemius and diaphragm when compared to those from C57 mdx mice; however, there were no differences detected in the left ventricle. Across all muscles, D2 mdx mice had the highest levels of oxidative stress as indicated by protein nitrosylation and/or nitration. In conclusion, our study shows that SERCA function is more impaired in young D2 mdx mice compared with age-matched C57 mdx mice.
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