Effect of Dietary Counseling on Patients with Asymptomatic Hyperuricemia

高尿酸血症 医学 无症状的 尿酸 指南 肾功能 人体测量学 尿检 内科学 痛风 尿 尿渗透压 肌酐 病理
作者
R Koike,Yuka Kawakami,Riho Kondo,Misaki Onishi,Misuzu Akiyama,Toshihiko Asai,Hidekazu Arai
出处
期刊:The Journal of Medical Investigation [University of Tokushima]
卷期号:70 (1.2): 34-40 被引量:1
标识
DOI:10.2152/jmi.70.34
摘要

In Japan, hyperuricemia is on the rise. The guideline for the management of hyperuricemia and gout recommends lifestyle changes before beginning drug therapy. This study aimed to evaluate the effectiveness of dietary counseling following the guideline. Thirty-three subjects (24 men and 9 women) with asymptomatic hyperuricemia underwent dietary counseling for 6 months based on the following recommendations : (1) prevent excessive purine intake, (2) prevent excessive fructose intake, (3) limit alcohol drinking, and (4) drink sufficient water. Obese subjects were counseled on adequate energy intake. Blood sampling, anthropometric measurements, dietary surveys, and 24-h urine collection were performed at baseline and at 6 months. Serum uric acid (S-UA) levels were significantly lower at 6 months compared to baseline. Water intake and urine volume were considerably higher at 6 months than at baseline. When compared to baseline, urine UA (U-UA) levels were significantly lower, and renal fractional excretion of UA (FEUA) was significantly higher at 6 months. Changes in renal function (serum creatinine, estimated glomerular filtration rate, and FEUA) were significantly associated with ?S-UA level. In this study, S-UA level was significantly decreased by dietary counseling in line with the guideline. This study illustrates the effectiveness of dietary counseling for asymptomatic hyperuricemia. J. Med. Invest. 70 : 34-40, February, 2023.
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