材料科学
分子印迹聚合物
纳米颗粒
聚合物
纳米技术
分子印迹
诺如病毒
热的
化学工程
病毒学
有机化学
选择性
复合材料
病毒
化学
物理
气象学
工程类
生物
催化作用
作者
Sarbjeet Kaur,Pankaj Singla,Amy Dann,Jake McClements,Mark V. Sullivan,Minji Kim,Sloane Stoufer,James A. Dawson,Robert D. Crapnell,Craig E. Banks,Nicholas W. Turner,Matthew D. Moore,Inderpreet Kaur,Marloes Peeters
标识
DOI:10.1021/acsami.4c01942
摘要
Norovirus (NoV) is the predominant cause of foodborne illness globally; current detection methods are typically expensive, have inadequate sensitivities, and utilize biological receptors with poor stability. Therefore, accurate, cost-effective, and highly stable detection methods are needed to screen for NoV in foods. We developed molecularly imprinted polymer nanoparticles (nanoMIPs) to detect NoV using a small target epitope (12 amino acids) with a solid-phase synthesis approach. The performance of three batches of nanoMIPs with varying monomer compositions (nanoMIP-1, -2, and -3) were compared both experimentally and computationally. Surface plasmon resonance examined nanoMIP binding affinity to norovirus virus-like particles (NoV-LPs), whereby nanoMIP-1 had the lowest K
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