The novel herbicide icafolin‐methyl is a plant‐specific inhibitor of tubulin polymerization

Without controlling weeds, it is estimated that about one third of global crop yields would be lost. Herbicides remain the most effective solution for weed control, but they face multiple challenges, such as the emergence and growth of resistant weed populations. Consequently, there is an urgent need for either herbicides with new modes of action or at least novel chemistries within established modes of action, with outstanding efficacy but without showing cross-resistance to the herbicides present in the prospective markets.