对称化
化学
环戊二烯基络合物
铑
催化作用
立体化学
药物化学
有机化学
对映选择合成
作者
Wen‐Qiang Wu,Pei‐Pei Xie,Leyao Wang,Bo‐Bo Gou,Yunzhi Lin,Liwei Hu,Chao Zheng,Shu‐Li You,Hang Shi
摘要
Owing to substantial advances in the past several decades, transition-metal-catalyzed asymmetric reactions have garnered considerable attention as pivotal methods for constructing chiral molecules from abundant, readily available achiral counterparts. These advances are largely attributed to the development of chiral ligands that control stereochemistry through steric repulsion and other noncovalent interactions between the ligands and functional groups or prochiral centers on the substrates. However, stereocontrol weakens dramatically with increasing distance between the reaction site and the functional group or prochiral center. Herein, we report a symphonic strategy for remote stereocontrol of Rh(III)-catalyzed asymmetric benzylic C-H bond addition reactions of diarylmethanes in which the two aryl motifs differ at the
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