类阿片
神经科学
控制(管理)
阿片肽
心理学
医学
计算机科学
内科学
受体
人工智能
作者
Guangjuan Yin,Kaifang Duan,Dong Dong,Du Feng,Chao Guo,Changyi Zhang,Xi Liu,Yuanjie Sun,Tianwen Huang,Guang-Fu Cui,Longzhen Cheng
出处
期刊:Neuron
[Elsevier]
日期:2024-10-01
标识
DOI:10.1016/j.neuron.2024.09.014
摘要
Repetitive use of morphine (MF) and other opioids can trigger two major pain-related side effects: opioid-induced hypersensitivity (OIH) and analgesic tolerance, which can be subclassified as mechanical and thermal. The central mechanisms underlying mechanical OIH/tolerance remain unresolved. Here, we report that a brain-to-spinal opioid pathway, starting from μ-opioid receptor (MOR)-expressing neuron in the lateral parabrachial nucleus (lPBN
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