Microneedles-mediated calcium-ion-modulated nanoamplifier for potentiating photodynamic therapy via specific-tuning assembly and tumor microenvironment remold

Off-targeting toxicity and immunosuppressive tumor microenvironment still restrict the therapeutic requirement of photodynamic therapy (PDT). The development of metal ion-coordination-based nanoparticles (NPs) for cancer therapy has advantages, such as precious nanostructure and potent therapeutic effect as well as great safety. In this study, we prepared calcium ions (Ca