Exercise Alleviates CUS-Induced Depressive-Like Behaviors by Modulating Paracellular and Transcellular Permeability of the Blood-Brain Barrier in the Prefrontal Cortex

Increased blood-brain barrier (BBB) permeability is implicated in the pathophysiology of major depressive disorder (MDD). While aerobic exercise has shown promise in mitigating MDD symptoms by potentially preserving BBB integrity, the detailed mechanisms remain unclear. This study explores these mechanisms to assess aerobic exercise's therapeutic potential for MDD.