Paradoxes in magnesium transport in Type 1 Bartter's syndrome and Gitelman's syndrome: a modeling analysis

Although changes in Ca 2+ excretion in type 1 Bartter’s syndrome and Gitelman’s syndrome are well understood, Mg 2+ excretion displays an interesting paradox. This computational modeling study provides insights into how renal adaptations in these two disorders impact Ca 2+ and Mg 2+ transport along different nephron segments. Model simulations showed that nephron adaptations favor Mg 2+ preservation over Ca 2+ in Bartter’s syndrome and Ca 2+ preservation over Mg 2+ in Gitelman’s syndrome and are stronger in females than in males.