Abstract High‐sensitive uncooled mid‐wave infrared (MWIR) photodetection with fast speed is highly desired for biomedical imaging, optical communication, and night vision technology. Low‐dimensional materials with low dark current and broadband photoresponse hold great promise for use in MWIR detection. Here, this study reports a high‐performance MWIR photodetector based on a titanium trisulfide (TiS 3 ) nanoribbon. This device demonstrates an ultra‐broadband photoresponse ranging from the visible spectrum to the MWIR spectrum (405–4275 nm). In the MWIR spectral range, the photodetector achieves competitive high photoresponsivity ( R ) of 21.1 A W −1 , and an impressive specific detectivity ( D *) of 5.9 × 10 10 cmHz 1/2 W −1 in ambient air. Remarkably, the photoresponse speed in the MWIR with τ r = 1.3 ms and τ d = 1.5 ms is realized which is much faster than the thermal time constant of 15 ms. These findings pave the way for highly sensitive, room‐temperature MWIR photodetectors with exceptionally fast response speed.