聚苯乙烯
材料科学
纳米技术
化学
化学工程
复合材料
聚合物
工程类
作者
Didar Baimanov,Zhuda Song,Zehao Zhang,Longxing Sun,Qingxi Yuan,Wanxia Huang,Yuxi Gao,Liming Wang,Zhiyong Zhang
出处
期刊:Nano Letters
[American Chemical Society]
日期:2024-10-03
被引量:7
标识
DOI:10.1021/acs.nanolett.4c03245
摘要
With the increasing presence of nanoplastics (NPs) in the human bloodstream, it is urgent to investigate their tissue accumulation and potential health risks. This study examines the effects of the size and surface charges of polystyrene (PS) NPs on lung accumulation. Using magnetic separation, we identified the protein corona composition on iron-core PS NPs, revealing the enrichment of vitronectin and fibrinogen. The corona promotes integrin αIIbβ3 receptor-mediated uptake by lung endothelial cells, explaining that both the corona composition and protein structure determine preferred localization of negatively charged PS NPs in the lung. This study uncovers the role of protein corona in NP uptake and the way NPs enter the lung, emphasizing the need to consider interactions between nanoplastics with varying surface characteristics and biological molecules in the nanotoxicological field.
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